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Xylitol Research

Milk with Xylitol for Dental Caries Prevention
(Jul 2005) Xylitol, a polyol sugar, has been shown to reduce dental caries when mixed with food or chewing gum. This study examines the taste acceptability of xylitol in milk as a first step toward measuring the effectiveness of xylitol in milk for the reduction of dental caries in a public health program. Dental Public Health Sciences, University of Washington, Seattle

Complementary and Alternative Medicine in Allergy, Otitis Media (Ear Infection), and Asthma
(Jul 2005) Studies suggest that probiotic preparations have a role in the treatment of allergic conditions, and Xylitol gum, syrup, and lozenges have shown efficacy in treatment of acute otitis media. Allegheny General Hospital, Integrated Medicine Program, Pittsburgh, PA. Curr Allergy Asthma Rep. 2005 Jul;5(4):313-8.

The Polyols in Pediatric Dentistry: Advantages of Xylitol
(Jul 2005) Xylitol is not only a means of stabilizing diabetes and obesity, but also a weapon in the prevention of dental caries. Arch Pediatr. 2005 Jul;12(7):1180-6.

Yogurt Containing Xylitol Lowered Appetite
(Jun 2005) The use of xylitol in functional foods resulted in suppression of appetite. Br J Nutr. 2005 Jun;93(6):911-5.

Xylitol in the Prevention of Oral Diseases
(Jun 2005) Review of studies for the inclusion of xylitol in primary preventive regimens as an adjunct for the prevention of oral diseases. Department of Periodontics, Endodontics and Dental Hygiene, University of Louisville School of Dentistry, Louisville, KY. Spec Care Dentist. 2005 May-Jun;25(3):140-4.

A Novel Method to Control the Balance of Skin Microflora. Studies to Assess the Effect of a Cream Containing Xylitol and Farnesol* on Atopic Dry Skin. Part 2
(Mar & Jun 2005) Staphylococcus aureus (SA) is usually present in atopic dry skin. It discharges various toxins and enzymes that injure the skin, and forms a biofilm that is resistance to anti-microbial agents. Even highly effective moisturizers do not work perfectly on atopic dry skin. Since treatment with anti-microbials may lead to re-growth of the bacteria, which often shows antibiotic resistance, this study searched for novel approaches to control the skin-microfloral balance without using conventional anti-microbials. The study found that xylitol inhibited the formation of glycocalyx, and the biofilm formation by SA. Xylitol has potential for controlling the skin-microfloral balance because of it's selective effects and inhibition of biofilm formation, and might provide a useful and safe method to care for skin colonized by SA, without using antibiotics. This study provides evidence supporting a cream containing Xylitol as a useful skin-care agent for atopic dry skin colonized by Staphylococcus aureus, a bacteria that can worsen atopic dermatitis (AD). Antibiotics and germicides are not the best choice to remove bacteria from the skin of AD patients, because of problems of irritation to the skin and bacterial resistance. Life Science Research Center, Yokohama, Japan. J Dermatol Sci. 2005 Jun;38(3):207-13. Epub 2005 Mar 2; J Dermatol Sci. 2005 Jun;38(3):197-205. Epub 2005 Mar 2.
*Farnesol - Natural ingredient found throughout the plant world which regulates developmental processes and is a natural bioactivator in human skin.

Evaluation of Fluoride Varnish and Xylitol Gum Prevention Programs
(May 2005) This study evaluated the effectiveness of two prevention programs, including applications of fluoride varnish and the use of xylitol chewing gum in randomized groups of preschool children in the United States. It showed that active noncavitated enamel lesions were common in the primary dentition of the children, and that applications of fluoride varnish may offer an effective means of arresting these early enamel lesions, and an efficient, non-surgical treatment for decay in children. It also showed that chewing xylitol gum reduced the levels of salivary mutans streptococci, thereby possibly reducing the risk for dental caries in these children. This research was carried out at the University of Florida, Gainesville, USA during the years 1997-2004 and at the Institute of Dentistry, University of Oulu, Finland during the years 2004-2005. Presentation at the Faculty of Medicine, University of Oulu, Institute of Dentistry, Finland May 2005.

Six-month Polyol Chewing-gum Program in Kindergarten-age Children: a Feasibility Study Focusing on Mutans Streptococci and Dental Plaque.
(Apr 2005) Xylitol-containing chewing gum may significantly reduce the growth of mutans streptococci and dental plaque which may be associated with dental caries. Sorbitol does not have the same effect. International Institute for Preventive Dentistry, University of Turku, Finland. Int Dent J. 2005 Apr;55(2):81-8.

The Effect of Xylitol and Ethanol on Bone Resorption
(Apr 2005) A simultaneous dietary supplementation with 10% xylitol and 10% ethanol seems to diminish bone resorption and to increase trabecular bone mineral density and trabecular bone mineral content in rats. Oral and Maxillofacial Department, Oulu University Hospital, Finland. Metabolism. 2005 Apr;54(4):548-51.

The Effect of an Oral Rinse Containing Xylitol for Elderly People with Xerostomia (Dry Mouth)
(Mar 2005) The results showed the usage of an oral rinse with Xylitol improved hyposalivation and unpleasant oral complaints of the elderly. Division of Gerontology and Gerodontology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan. Kokubyo Gakkai Zasshi. 2005 Mar;72(1):106-10.

New Study Indicates That Popular Sports Beverages Cause More Irreversible Damage to Teeth Than Soda
(Feb. 2005) While sports and energy drinks help athletes re-hydrate after a long workout, if consumed on a regular basis they can damage teeth. These beverages may cause irreversible damage to dental enamel, potentially resulting in severe tooth decay according to a study reported in the January/February issue of General Dentistry, the Academy of General Dentistry 's clinical, peer-reviewed journal.

The Effect of Xylitol Chewing Gum on Mutans Streptococci in Saliva and Dental Plaque
(Dec 2004) This study conducted with 91 children suggests that the use of xylitol chewing gum can reduce the levels of mutans streptococci in plaque and saliva. Department of Microbiology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. Southeast Asian J Trop Med Public Health. 2004 Dec;35(4):1024-7.

Further Evidence of How Xylitol Prevents Ear Infections: Ultrastructure of Streptococcus Pneumoniae after Exposure to Xylitol
(Jul 2004) Xylitol is a sugar alcohol which reduces the growth of Streptococcus pneumoniae and the adherence of pneumococci and Haemophilus influenzae to nasopharyngeal cells. Xylitol prevents acute otitis media but does not decrease nasopharyngeal carriage of pneumococci. The researchers hypothesized that xylitol could affect the surface structures of viable pneumococci, which would further explain the mechanism of action of xylitol in preventing acute otitis media. This study demonstrates further that xylitol has a harmful effect on pneumococci. The observed changes in the polysaccharide capsule and the cell wall of pneumococci could affect the adherence and virulence of pneumococci, explaining the good clinical efficacy of xylitol in the prevention of acute otitis media. Department of Pediatrics, University of Oulu, Oulu, Finland. J Antimicrob Chemother. 2004 Jul;54(1):225-8. Epub 2004 Jun 9.

Army's "Look for Xylitol First" Program
(Apr 2004) Xylitol is a sugar substitute not well known in the United States. This sugar substitute is not only low in calories but can also help prevent dental caries. The U.S. Army Dental Command's Health Promotion Program is constantly seeking additional prevention measures to enhance the oral health of America's Army. The Dental Command has created the "Look for Xylitol First" initiative aimed at training all members of the dental care team on the positive benefits of xylitol and to teach patients how to be smart consumers and evaluate products for their xylitol content. Dental Corps, U.S. Army Dental Command, Fort Sam Houston, Texas. Dent Assist. 2004 Mar-Apr;73(2):38-40.

Poor Oral Health Associated with Coronary Heart Disease
(Feb. 2004) Having poor scores in five areas of oral health is associated with coronary heart disease, according to a report in Circulation: Journal of the American Heart Association. Among the five oral diseases, the strongest predictor of coronary disease was pericoronitis, followed by root remnants and gingivitis; then dental caries and missing teeth. This study suggests oral disease and coronary heart disease are linked. A poor oral health diagnosis was a stronger predictor of heart disease than high levels of fibrinogen (a clotting factor), low HDL (“good”) cholesterol or high triglycerides.

The Majority of 3rd Grade Students (44%-72%) of Have Dental Decay
Dental caries is the single most common chronic disease of childhood, occurring five to eight times as frequently as asthma, the second most common chronic disease in children, according to the National Oral Health Surveillance System.

Xylitol and Dental Caries: An Overview for Clinicians
JOURNAL OF THE CALIFORNIA DENTAL ASSOCIATION
(Mar 2003) An overview of studies about xylitol and dental caries suggests potential clinical dental applications for xylitol. Xylitol is a naturally occurring, low-calorie sugar substitute with anticariogenic properties. Data from recent studies indicate that xylitol can reduce the occurrence of dental caries in young children, schoolchildren, and mothers, and in children via their mothers. Xylitol, a sugar alcohol, is derived mainly from birch and other hardwoods trees. Short-term consumption of xylitol is associated with decreased Streptococcus mutans levels in saliva and plaque. Aside from decreasing dental caries, xylitol may also decrease the transmission of S. mutans from mothers to children. Commercial xylitol-containing products may be used to help control rampant decay in primary dentition. Studies of schoolchildren in Belize and Estonia, along with data from the University of Washington, indicate that xylitol gum, candy, ice pops, cookies, puddings, etc., in combination with other dental therapies, are associated with the arrest of carious lesions. A prospective trial in Finland has demonstrated that children of mothers treated with xylitol had lower levels of S. mutans than children of mothers treated with chlorhexidine or fluoride varnish. Food products containing xylitol are available commercially and through specialized manufacturers, and have the potential to be widely accessible to consumers.

Use of Chewing Gums Containing Xylitol, Chlorhexidine or Fluoride on Mutans Streptococci Colonization by the Mothers' Infant Children
(2003) Maternal consumption of xylitol- and chlorhexidine/xylitol-containing chewing gums significantly reduced the mother-child transmission of salivary mutans streptococci. Public Dental Clinic, Varberg, Sweden. Oral Health Prev Dent. 2003;1(1):53-7.

Effect of Xylitol-containing Chewing Gums on Lactic Acid Production in Dental Plaque from Caries Active Pre-school Children
(2003) A 14-day use of xylitol-containing chewing gums, corresponding to a daily amount of 5 grams of xylitol, could diminish glucose-initiated lactic acid formation in plaque in caries-active pre-school children. Department of Odontology/Paediatric Dentistry, Faculty of Medicine and Odontology, Umea University, Umea, Sweden. Oral Health Prev Dent. 2003;1(3):195-9.

Remineralization Effects of Xylitol on Demineralized Enamel
(2003) This study shows that xylitol can induce remineralization of deeper layers of demineralized enamel by facilitating Ca2+ movement and accessibility. Department of Ultrastructural Science, Oral Health Science Center, Tokyo Dental College. J Electron Microsc (Tokyo). 2003;52(5):471-6.

Nasal Benefits

The osmolyte xylitol reduces the salt concentration of airway surface liquid and may enhance bacterial killing .
Zabner J, Seiler MP, Launspach JL, Karp PH, Kearney WR, Look DC, Smith JJ, Welsh MJ..
1/1/2002 12:00:00 AM. • "xylitol sprayed for 4 days into each nostril of normal volunteers significantly decreased the number of nasal coagulase-negative Staphylococcus compared with saline control."

Xylitol in preventing acute otitis media .
Uhari M, Tapiainen T, Kontiokari T..
12/1/2000 12:00:00 AM. • "Xylitol inhibits the growth of Streptococcus pneumoniae and it inhibits the attachment of both pneumococci and Haemophilus influenzae on the nasopharyngeal cells. In two clinical trials xylitol was found efficient to prevent the development of acute otitis media with a daily dose of 8.4-10 g of xylitol given in five divided doses. "

A novel use of xylitol sugar in preventing acute otitis media .
Uhari M, Kontiokari T, Niemela M..
10/1/1998 12:00:00 AM. • "Thus, the occurrence of AOM (ear infection) during the follow-up period was significantly lower in those who received xylitol syrup or gum, and these children required antimicrobials less often than did controls. Xylitol was well tolerated."

Studies on the Cavity-fighting Effectiveness of Xylitol

Alanen P, et al. (2000). Xylitol candies in caries prevention: results of a field study in Estonian children. Community Dent Oral Epidemiol. 28(3):218-24. ( See abstract )

Autio JT. (2002). Effect of xylitol chewing gum on salivary Streptococcus mutans in preschool children. ASDC J Dent Child. 69(1):81-6, 13. ( See abstract )

Calamari SE, et al. (1997). Effects of xylitol, sorbitol and fluoride mouth rinses on glucose clearance in adolescents. Acta Odontol Latinoam.10(1):25-36. ( See abstract )

Edgar WM. (1998). Sugar substitutes, chewing gum and dental caries--a review. Br Dent J. 184(1):29-32. ( See abstract )

Gales MA, Nguyen TM. (2000). Sorbitol compared with xylitol in prevention of dental caries. Ann Pharmacother. 34(1):98-100. ( See abstract )

Hayes C. (2001). The effect of non-cariogenic sweeteners on the prevention of dental caries: a review of the evidence. J Dent Educ. 65(10):1106-9.( See abstract )

Hildebrandt GH, Sparks BS. (2000). Maintaining mutans streptococci suppression with xylitol chewing gum. J Am Dent Assoc. 131(7):909-16. ( See abstract )

Honkala S, et al. (1999). Use of xylitol chewing gum among Finnish schoolchildren. Acta Odontol Scand. 57(6):306-9. ( See abstract )

Hujoel PP, et al. (1999). The optimum time to initiate habitual xylitol gum-chewing for obtaining long-term caries prevention. J Dent Res. 78(3):797-803. ( See abstract )

Isokangas P, et al. (2000). Occurrence of dental decay in children after maternal consumption of xylitol chewing gum, a follow-up from 0 to 5 years of age. J Dent Res. 79(11):1885-9. ( See abstract )

Isogangas P, et al. (1993). Long-term effect of xylitol chewing gum in the prevention of dental caries: a follow-up 5 years after termination of a prevention program. Caries Res. 27(6):495-8. ( See abstract )

Machiulskiene V, et al. (2001). Caries preventive effect of sugar-substituted chewing gum. Community Dent Oral Epidemiol. 20 29(4):278-88. ( See abstract )

Makinen KK, et al. (1998). Physical, chemical, and histologic changes in dentin caries lesions of primary teeth induced by regular use of polyol chewing gums. Acta Odontol Scand. 56(3):148-56. ( See abstract )

Makinen KK, et al. (1998). A descriptive report of the effects of a 16-month xylitol chewing-gum programme subsequent to a 40-month sucrose gum programme. Caries Res. .32(2):107-12. ( See abstract )

Makinen KK, et al. (1996). Conclusion and review of the Michigan Xylitol Programme (1986-1995) for the prevention of dental caries. Int Dent J. 46(1):22-34. ( See abstract )

Makinen KK, et al. (1996). Polyol-combinant saliva stimulants and oral health in Veterans Affairs patients--an exploratory study. Spec Care Dentist. 16(3):104-15. ( See abstract )

Petersson LG, et al. (1991). Caries-preventive effect of dentifrices containing various types and concentrations of fluorides and sugar alcohols. Caries Res. 25(1):74-9. ( See abstract )

Rekola M. (1986). Changes in buccal white spots during 2-year consumption of dietary sucrose or xylitol. Acta Odontol Scand. 44(5):285-90. ( See abstract )

Roberts MC, et al. (2002). How xylitol-containing products affect cariogenic bacteria. J Am Dent Assoc. 133(4):435-41. ( See abstract )

Scheie AA, Fejerskov OB. (1998). Xylitol in caries prevention: what is the evidence for clinical efficacy? Oral Dis. 4(4):268-78. ( See abstract )

Scheinin A, et al. (1993). Xylitol-induced changes of enamel microhardness paralleled by microradiographic observations. Acta Odontol Scand. 51(4):241-6. ( See abstract )

Scheinin A, et al. (1985). Collaborative WHO xylitol field studies in Hungary. VII. Two-year caries incidence in 976 institutionalized children. Acta Odontol Scand. 43(6):381-7. ( See abstract )

Simons D, et al. (2002). The effect of medicated chewing gums on oral health in frail older people: a 1-year clinical trial. J Am Geriatr Soc. 50(8):1348-53. ( See abstract )

Simons D, et al. (1999). The effect of xylitol and chlorhexidine acetate/xylitol chewing gums on plaque accumulation and gingival inflammation. J Clin Periodontol. 26(6):388-91. ( See abstract )

Soderling E, et al. (2000). Influence of maternal xylitol consumption on acquisition of mutans streptococci by infants. J Dent Res. 79(3):882-7. ( See abstract )

Soderling E, et al. (1991). Long-term xylitol consumption and mutans streptococci in plaque and saliva. Caries Res. 25(2):153-7. ( See abstract )

Soderling E, Scheinin A. (1991). Perspectives on xylitol-induced oral effects. Proc Finn Dent Soc. 87(2):217-29. ( See abstract )

Steinberg LM, et al. (1992). Remineralizing potential, antiplaque and antigingivitis effects of xylitol and sorbitol sweetened chewing gum. Clin Prev Dent. 14(5):31-4. ( See abstract )
Tanzer JM. (1995). Xylitol chewing gum and dental caries. Int Dent J. 45(1 Suppl 1):65-76. ( See abstract )

Trahan L, et al. (1996). Emergence of multiple xylitol-resistant (fructose PTS-) mutants from human isolates of mutans strep tococci during growth on dietary sugars in the presence of xylitol. J Dent Res. 75(11):1892-900. ( See abstract )

Xylitol and dental caries: an overview for clinicians .
Lynch H, Milgrom P..
3/31/2003 12:00:00 AM. • A prospective trial in Finland has demonstrated that children of mothers treated with xylitol had lower levels of S. mutans (bacteria) than children of mothers treated with chlorhexidine or fluoride varnish.

Xylitol for caries prevention .
Peldyak J, Makinen KK.
10/1/2002 12:00:00 AM. • "The appealing sensory and functional properties of xylitol facilitate a wide arrary of applications that promote oral health."

The optimum time to initiate habitual xylitol gum-chewing for obtaining long-term caries prevention .
Hujoel PP, Makinen KK, Bennett CA, Isotupa KP, Isokangas PJ, Allen P, Makinen PL.
3/1/2002 12:00:00 AM. • "Habitual xylitol gum-chewing may have a long-term preventive effect by reducing the caries risk for several years after the habitual chewing has ended."

The effect of non-cariogenic sweeteners on the prevention of dental caries: a review of the evidence .
Hayes C.
1/1/2002 12:00:00 AM. • These studies observed the reduction of cavity rates among subjects using xylitol and sorbitol as the sugar substitutes in chewing gum and toothpaste. The highest cavity reductions were observed in subjects using xylitol.

Remineralizing potential, antiplaque and antigingivitis effects of xylitol and sorbitol sweetened chewing gum .
Steinberg LM, Odusola F, Mandel ID..
1/1/2002 12:00:00 AM. • "Chewing xylitol and sorbitol gums reduced plaque accumulation and gingival inflammation. In addition, both gums enhanced the remineralization potential of plaque. Xylitol gum showed a superior effect with respect to remineralization potential and plaque reduction. "

Smart Habit Xylitol campaign, a new approach in oral health promotion .
Nordblad A, Suominen-Taipale L, Murtomaa H, Vartiainen E, Koskela K..
1/1/2002 12:00:00 AM. • The aim of the campaign was to increase consumption of xylitol chewing gum in 13-year-old school children, to promote their oral health.

Effect of xylitol chewing gum on salivary Streptococcus mutans in preschool children .
Autio JT.
1/1/2002 12:00:00 AM. • "The shift from higher S. mutans (bacteria) scores to lower was greater in the xylitol group than in the control group. This study supports the suggestion that chewing xylitol gum may reduce S. mutan levels."

Caries preventive effect of sugar-substituted chewing gum .
Machiulskiene V, Nyvad B, Baelum V.
1/1/2002 12:00:00 AM. •

Acceptance of the xylitol chewing gum regimen by preschool children and teachers in a Head Start program: a pilot study .
Autio JT, Courts FJ..
1/1/2002 12:00:00 AM. •

Comparison of erythritol and xylitol saliva stimulants in the control of dental plaque and mutans streptococci .
Makinen KK, Isotupa KP, Kivilompolo T, Makinen PL, Toivanen J, Soderling E..
1/1/2002 12:00:00 AM. •

An evaluation of a commercial chewing gum in combination with normal toothbrushing for reducing dental plaque and gingivitis .
Sharma NC, Galustians JH, Oaqish JG..
7/22/2001 12:00:00 AM. •

Use of xylitol chewing gum among Finnish schoolchildren .
Honkala S, Honkala E, Tynjala J, Kannas L..
12/1/1999 12:00:00 AM. •

Sugar substitutes, chewing gum and dental caries--a review .
Edgar WM..
1/1/1998 12:00:00 AM. • Clinical trials indicate that xylitol gum has a useful anticaries role, superior to the effects of sorbitol gum. In addition, xylitol's antibacterial properties seem likely to lead to caries reductions superior to the more modest reductions with sorbitol gum.

Effects of xylitol, sorbitol and fluoride mouthrinses on glucose clearance in adolescents .
Calamari SE, Azcurra AI, Luna Maldonado ER, .
10/1/1997 12:00:00 AM. • "Since the sugars salivary clearance is part of a process intended to prevent dental caries, our results suggest that xylitol adds antoher mechanism of action to its well known cariostatic and anticaries properties."

Effects of frequent mouthrinses with palatinose and xylitol on dental plaque .
Lingstrom P, Lundgren F, Birkhed D, Takazoe I, Frostell G..
4/1/1997 12:00:00 AM. • "Regarding the plaque index, xylitol gave lower scores compared to the other 3 periods."

Timing of first restorations before, during, and after a preventive xylitol trial .
Virtanen JI, Bloigu RS, Larmas MA..
8/1/1996 12:00:00 AM. • This analysis indicated that participation of subjects in the xylitol chewing gum trials resulted in a significant reduction in the number of first restorations and hence in costs during the decade after the onset of gum use.

Xylitol fermentation by human dental plaque .
Assev S, Waler SM, Rolla G..
8/1/1996 12:00:00 AM. •

Properties of whole saliva and dental plaque in relation to 40-month consumption of chewing gums containing xylitol, sorbitol of sucrose .
Makinen KK, Chen CY, Makinen PL, Bennett CA, Isokangas PJ, Isotupa KP, Pape HR Jr..
3/1/1996 12:00:00 AM. •

Chewing of xylitol gum--a well adopted practice among finnish adolescents .
Honkala E, Rimpela A, Karvonen S, Rimpela M.
1/1/1996 12:00:00 AM. • "The increase in use of xylitol chewing gum is an example of the positive effect of health education given by a comprehensive, preventively oriented system of dental health care in association with commercial interests."

Xylitol chewing gums and caries rates: a 40-month cohort study .
Makinen KK, Bennett CA, Hujoel PP, Isokangas PJ, Isotupa KP, Pape HR Jr, Makinen PL..
12/1/1995 12:00:00 AM. • "The four xylitol gums were most effective in reducing caries rates, the most effective agent being a 100% xylitol pellet gum. This gum was superior to any other gum."

Chewing gum and dental health. Literature review .
Toors FA.
1/1/1992 12:00:00 AM. • "Prolonged use of xylitol or xylitol containing chewing gum reduces Streptococcus mutans counts in plaque and saliva, at the same time fostering remineralization of early caries lesions. Regular use of xylitol reduces the acidogenic potential of the plaque as well as its adhesiveness, at the same time increasing its mineral content."

Xylitol as a Sweetener

Effect of xylitol on growth of Streptococcus pneumoniae in the presence of fructose and sorbitol .
Tapiainen T, Kontiokari T, Sammalkivi L, Ikaheimo I, Koskela M, Uhari M..
1/1/2002 12:00:00 AM. • "Thus, it seems that xylitol is the only commercially used sugar substitute proven to have an antimicrobial effect on pneumococci."

A dietary procedure for preventing dental caries in young adults .
Makinen KK..
1/1/2002 12:00:00 AM. • "Scientific evidence also suggests that the addition of small daily quantities of xylitol to the diet of children and young adults causes significant reduction in the incidence of dental caries."

Children's acceptance of xylitol-based foods .
Lam M, Riedy CA, Coldwell SE, Milgrom P, Craig R..
1/1/2002 12:00:00 AM. • "These results suggest that snack foods developed with xylitol are generally well accepted by children."

Food components and caries .
Bowen WH.
1/1/2002 12:00:00 AM. • "For instance, replacing sugar in foods with xylitol, sorbitol, saccharin, or aspartame may lead to a reduction in the incidence of dental caries."

Organoleptic properties of a new sweetening agent formulation based on aspartame and xylitol .
Dumas P, Sauvageot F.
1/1/2002 12:00:00 AM. • "The results show that the aspartame-xylitol mixture with sweetness intensity equal to 5.0 is a good synthetic sweetner to substitute sucrose."

Sugar, alternative sweeteners and meal frequency in relation to caries prevention: new perspectives .
Kandelman D.
4/1/1997 12:00:00 AM. • "The use of chewing gum and other xylitol-containing products have resulted in defined reduction in caries and represent interesting alternatives for high-caries-risk populations."

For Sensitive Teeth

Nasal Benefits

Studies on the Cavity-fighting Effectiveness of Xylitol

Xylitol as a Sweetener

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